反应详情

A solution of tert-butyl 3-[(3-(benzyloxy)-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate (90 mg, 0.144-mmol) in 1:1 mixture of THF/ethanol was evacuated and purged with nitrogen (×3). 10% Palladium on carbon was added and the reaction mixture was evacuated and purged with nitrogen and then evacuated and finally purged with hydrogen gas. The reaction mixture was left to stir at ambient temperature under an atmosphere of hydrogen for 6 hours. The Palladium catalyst was filtered through diatomaceous earth. The filtrate was evaporated to give a crude solid (70 mg)

1. customwas evacuated
2. custompurged with nitrogen (×3)
3. addition10% Palladium on carbon was added
4. customthe reaction mixture was evacuated
5. custompurged with nitrogen
6. customevacuated
7. customfinally purged with hydrogen gas
8. waitThe reaction mixture was left
9. filtrationThe Palladium catalyst was filtered through diatomaceous earth
10. customThe filtrate was evaporated