反应详情

8.6 g of 1,3-dimethyl-4-[(2-nitrophenyl)amino]pyrazole-5-carboxamide in 400 ml of ethanol are hydrogenated over 0.8 g of 10% strength palladium-on-charcoal for 1 hour at 50° C. analogously to Experiment 1. The mixture is filtered; the filtrate is concentrated to dryness, and the residue from evaporation is recrystallized from 160 ml of ethyl acetate and 120 ml of cyclohexane to yield 7.1 g of 4-[(2-aminophenyl)amino]-1,3-dimethylpyrazole-5-carboxamide, mp 182° to 184° C. (dec.).

1. filtrationThe mixture is filtered
2. concentrationthe filtrate is concentrated to dryness
3. customthe residue from evaporation
4. customis recrystallized from 160 ml of ethyl acetate and 120 ml of cyclohexane