Urea → HCID 178513087, compound

Participants

Reaction Steps

The compound of Example 1 was prepared by adding dropwise to 4.3 g (0.015 mols) 2-(2,6-dichlorophenyl)-2-bromo-acetic acid in 50 ml acetone 1.6 g (0.008 mols) dicyclohexyl carbodiimide in 10 ml acetone over a period of 15 minutes. After filtration of the urea, dropwise addition of 1.35 g (0.015 mols) S-methylisothiourea in 25 ml acetone is carried out. Thirty minutes later, the precipitate is suction-filtered, the filtrate evaporated and the residue mixed with acetone and suction-filtered once again. The product of the first stage is S-Methyl-N-[2-(2,6-dichlorophenyl)-2-bromo-acetyl] isothiourea. The decomposition point is 175 degrees C.

Provenance & Evidence