Sodium Methoxide → HCID 20549426, compound

HRID 2058654Notes

Reaction equation

HRID 2058654 reaction equation
C[O:2][C:3](=[O:14])[CH:4](Br)[C:5]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:12].[CH3:15][O-:16].[Na+]>CO>[Cl:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([Cl:11])[C:5]=1[CH:4]([O:16][CH3:15])[C:3]([OH:2])=[O:14]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 1938564677583-73-4

Product 1

HCID 20549426HCID 20549426, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 g (0.033 mols) 2 bromo-2(2,6-dichlorophenyl)-acetic acid methyl ester (Example 8) are heated with sodium methylate in methanol (1.6 g Na in 100 ml MeOH) in an autoclave for 5 hours at 150 degrees C. After evaporation of the solvent, the residue is taken up in a water-chloroform mixture. By acidification of the aqueous phase, 3.9 g 2-(2,6-dichlorophenyl)-2-methoxy-acetic acid is obtained. It melts at 119-122 degrees C. after recrystallization from diisopropyl ether.

Workup

  1. customAfter evaporation of the solvent

Sources & evidence

ORD record
ord-6be53615c69c48268ed37c5d4fd8b8a5
Source dataset
uspto-grants-1982_03
Patent number
US04318915

Reaction notes

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