HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 2-(Bromomethyl)-4-chloro-1-fluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 5-Chloro-2-fluorotoluene | HCID 2725113 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 2-(Bromomethyl)-4-chloro-1-fluorobenzene | HCID 2773626 | — |
Reaction Steps
A mixture of 5-chloro-2-fluorotoluene (2.9 g; prepared by a modified Schiemann reaction on 4-chloro-2-methylaniline), NBS (3.6 g) benzoyl peroxide (100 mg) and carbon tetrachloride (25 ml) was refluxed 2h. The mixture was cooled, filtered and the solvent removed. Distillation gave 5-chloro-2-fluorobenzyl bromide (3 g), b.p. 104°/15 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04318909 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-7bd33f0403724bdc86fc45d7e27d9ca0 |
| Source note | uspto-grants-1982_03 |