HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 2-[[[3-(1-Piperidinylmethyl)phenyl]methyl]thio]ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Cysteamine Hydrochloride | HCID 9082 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (3-((Piperidin-1-yl)methyl)phenyl)methanol | HCID 7164645 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2-[[[3-(1-Piperidinylmethyl)phenyl]methyl]thio]ethanamine | HCID 21297544 | 68.4% |
Reaction Steps
A mixture of 3-(1-piperidinylmethyl)benzenemethanol (10.8 g) and cysteamine hydrochloride (6.48 g) in concentrated hydrochloric acid (25 ml) was heated at 100° for 3 h. The cooled mixture was added to ether (500 ml) and treated with an excess of sodium carbonate. The organic solution was filtered and distilled to give the title compound as an oil (9.51 g) b.p. 175° (6×10-2 mm). TLC silica; ethyl acetate:water:isopropanol:0.88 ammonia 25:8:15:2; Rf 0.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04318913 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-c7d0dc9eacc94c07946ff86cde3c0c28 |
| Source note | uspto-grants-1982_03 |