HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Lamtidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine | HCID 10220561 | — |
| Reactant | methyl N-cyano-1-methyl-2-(phenylmethylene)-hydrazinecarboximidothioate | HCID 54323404 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Lamtidine | HCID 71988 | 28.5% |
Reaction Steps
3-[3-[1-Piperidinylmethyl]phenoxy]propanamine (2.48 g) and N-cyano-1-methyl-2-(phenylmethylene)hydrazine carboximidothioic acid, methyl ester (2.32 g) were heated at 70° under water-pump vacuum for 4 hr. Acetone was added and the solution was treated with dilute hydrochloric acid for 1 hr, washed with ether, basified and extracted with ethyl acetate. Evaporation of the ethyl acetate extracts gave an oil which crystallised from toluene/ether to give the title compound as a white solid (0.98 g) m.p. 94°-5°. TLC silica, methanol/0.88 ammonia 80:1, Rf 0.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04318913 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-2994e54391aa44929a578e03540b22b5 |
| Source note | uspto-grants-1982_03 |