Hydrochloric Acid → Lamtidine

Participants

Reaction Steps

A solution of 1-methyl-N5 -[3-[3-(1,3-dioxolan-2-yl) phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine (106 mg) in tetrahydrofuran (2 ml) was stirred with 2N hydrochloric acid (0.2 ml) for 1/2 h at room temperature. The mixture was treated with piperidine (0.5 ml), stirred at room temperature for 1 h, and then treated with sodium borohydride (75 mg). After a further 1 h, the mixture was diluted with water, and extracted with ethyl acetate. The combined extracts were dried and evaporated in vacuo. The resulting oil was crystallised from a mixture of benzene and cyclohexane to yield the title compound (60 mg) m.p. 93°-4° . TLC silica (methanol:ammonia 80:1) Rf 0.5.

Provenance & Evidence