Methylhydrazine → 2-(1-Methylhydrazino)benzoxazole

HRID 2058780Notes

Reaction equation

HRID 2058780 reaction equation
[CH3:1][NH:2][NH2:3].Cl[C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1>CCOCC>[CH3:1][N:2]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1)[NH2:3]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 119862-Chlorobenzoxazole

Product 1

HCID 129616282-(1-Methylhydrazino)benzoxazole

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To an ice cooled solution of 16.2 ml. of methylhydrazine in 100 ml. of dry ether is added 10.8 g. of 2-chlorobenzoxazole at a dropwise rate, keeping the temperature below 25° C. The mixture is stirred 30 min. in the ice bath and 2 hours at room temperature and then carefully evaporated. The residue is slurried with 200 ml. cold water, filtered, washed and dried to give 9.5 g. of 2-(1-methylhydrazine)benzoxazole, m.p. 128°-31°.

Workup

  1. customthe temperature below 25° C
  2. customcarefully evaporated
  3. filtrationcold water, filtered
  4. washwashed
  5. customdried
  6. customto give 9.5 g

Sources & evidence

ORD record
ord-df069c6616b442c988659984486def04
Source dataset
uspto-grants-1982_03
Patent number
US04319026

Reaction notes

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