Morpholine → HCID 53905837, compound

HRID 2058791Notes

Reaction equation

HRID 2058791 reaction equation
[CH2:1]([C:8](=[CH:11]OCC)[C:9]#[N:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[CH2:1]([C:8](=[CH:11][N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)[C:9]#[N:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 54191127HCID 54191127, compound

Product 1

HCID 53905837HCID 53905837, compoundYield 40.3%

Procedure

9.35 g (0.05 mol) of 2-benzyl-3-ethoxyacrylonitrile and 17.4 g (0.2 mol) of morpholine are refluxed for 20 h. Subsequent vacuum distillation yields 4.6 g of 2-benzyl-3-morpholinoacrylonitrile (81% with respect to the reacted 2-benzyl-3-ethoxyacrylonitrile (50%).

Workup

  1. distillationSubsequent vacuum distillation

Sources & evidence

ORD record
ord-8000b1cb00f94955b761bf2a6562d43b
Source dataset
uspto-grants-1982_03
Patent number
US04319024

Reaction notes

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