反应详情

5,5,7-Trimethyl-4,5,6,7-tetrahydrobenzothiazol-2-yl isocyanate dimer (7.5 grams), the dimethyl acetal of 2-methyl-aminoacetaldehyde (5 grams) and toluene (15 ml) were charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture was then heated, with stirring for a period of about 1 hour. After this time the mixture was cooled and filtered. The filtrate was washed with water, dried and evaporated, leaving the desired product dimethyl acetal of 2-[1-methyl-3-(5,5,7-trimethyl-4,5,6,7-tetrahydrobenzothiazol-2-yl)ureido]acetaldehyde as a brown oil.

1. customequipped with a mechanical stirrer
2. temperaturereflux condenser
3. temperatureThe reaction mixture was then heated
4. temperatureAfter this time the mixture was cooled
5. filtrationfiltered
6. washThe filtrate was washed with water
7. customdried
8. customevaporated