Methylamine → HCID 20548484, compound

Participants

Reaction Steps

A 1.5 g. portion of 1-(3-fluorophenyl)-2,4-pentanedione was reacted with 15 ml. of N,N-dimethylformamide dimethyl acetal, and then with 10 ml. of 40% aqueous methylamine as described in Example 4. The reaction mixture was then evaporated under vacuum to dryness, and the crude product was chromatographed on a silica gel column with ethyl acetate to obtain 1 g. of the desired product, which was identified by nmr analysis in CDCl3, showing peaks at δ8.1-8.2 (m, 1H, pyridine); 6.9-7.6 (m, 5H, phenyl and 1 pyridine); 3.80 (s, 3H, N--CH3); 2.83 (s, 3H, COCH3).

Provenance & Evidence