Dimethylformamide dimethyl acetal → HCID 20548512, compound

Participants

Reaction Steps

A 1.3 g. portion of impure 5-methyl-1-(3-trifluoromethylphenyl)-2,4-heptanedione was reacted with 50 ml. of N,N-dimethylformamide dimethyl acetal, and then with 2 g. of methylamine hydrochloride as described in Example 12. The impure product was purified as described in Example 12, except that the final product was subjected to an additional step of trituration under hexane to obtain 0.08 g. of the desired product, m.p. 109°-111°, showing the following nmr peaks in CDCl3 : δ7.3-8.1 (m, 6H, aromatic); 3.9-4.2 (m, 1H, COCH); 3.8 (s, 3H, N--CH3); 1.2-2.0 (m, 2H, CH2CH3); 1.1-1.2 (d, 3H, CHCH3); 0.8-1.1 (t, 3H, CH2CH3).

Provenance & Evidence