1-(2-Chlorophenyl)piperazine → HCID 20548788, compound

Participants

Reaction Steps

1,2-Epoxy-3-(2,2-dimethylchroman-4-on-7-yl)oxypropane (7.6 g) and N-(o-chlorophenyl)-piperazine (6.04 g) were heated under reflux in ethanol (150 ml) for 3 hours. The solution was evaporated to dryness in vacuo and treated with an excess of ethanolic hydrogen chloride and evaporated to dryness in vacuo. The residue was crystallised from ethanol/ether to give 1-(4-(o-chlorophenyl)-piperazino)-3-(2,2-dimethylchroman-4-on-7-yl)oxypropan-2-ol hydrochloride (11.07 g), m.p. 169°-173° C.

Provenance & Evidence