HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2059021Generated: October 31, 2026
5,6,7,8-Tetrahydro-1-naphthol → 5,6,7,8-Tetrahydro-1-naphthyl-nicotinate
https://huagongshe.com/reaction/2059021
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5,6,7,8-Tetrahydro-1-naphthol | HCID 68258 | — |
| Reactant | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5,6,7,8-Tetrahydro-1-naphthyl-nicotinate | HCID 12940115 | — |
Reaction Steps
7 g (47 mmol) of 5,6,7,8-tetrahydro-1-naphthol and 9 g (50 mmol) of nicotinic acid chloride hydrochloride was mixed with 130 ml of dry pyridine and stirred for 24 hours at 30° C. After cooling precipitated pyridine hydrochloride was sucked off, and the filtrate mixed with 300 ml of water. The precipitated raw product was washed with two 200 ml portions of water and recrystallized from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04321268 |
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| Source dataset | uspto-grants-1982_03 |
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| ORD ID | ord-3f0123d030bd4c188eeaae5e72c3334a |
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| Source note | uspto-grants-1982_03 |
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