Water → 4,5-Diethylthiazol-2-ylcarbamoylcarboxylic Acid

Participants

Reaction Steps

Ethyl 4,5-diethylthiazol-2-ylcarbamoylcarboxylate (897 mg., 3.5 mmoles), 1 N potassium carbonate (3.5 ml., 3.5 equivalents) and 27 ml. of water were combined and heated on a steam bath for 10 minutes. Clear solution was noted after 5 minutes. The reaction mixture was cooled and made acidic with acetic acid. Crude product (625 mg.) was recovered by filtration. Recrystallization from approximately 33 ml. of absolute ethanol gave purified 4,5-diethylthiazol-2-ylcarbamoylcarboxylic acid [470 mg.; m.p. 206° C. (dec.)].

Provenance & Evidence