Ammonia → HCID 20548215, compound

HRID 2059063Notes

Reaction equation

HRID 2059063 reaction equation
C([O:3][C:4]([C:6]1[C:11](=[O:12])[N:10]2[CH:13]([CH3:22])[CH2:14][CH2:15][C:16]([C:17]([N:19]([CH3:21])[CH3:20])=[O:18])=[C:9]2[NH:8][CH:7]=1)=O)C.[NH3:23]>C(O)C>[NH2:23][C:4]([C:6]1[C:11](=[O:12])[N:10]2[CH:13]([CH3:22])[CH2:14][CH2:15][C:16]([C:17]([N:19]([CH3:21])[CH3:20])=[O:18])=[C:9]2[NH:8][CH:7]=1)=[O:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20548233HCID 20548233, compound

Product 1

HCID 20548215HCID 20548215, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

3.07 g. of 3-ethoxycarbonyl-6-methyl-9-(N,N-dimethylamino-carbonyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido[1,2-a]pyrimidine are dissolved in ethanol. To the solution a 20% by W/V solution of ammonia in ethanol is added and the reaction mixture is allowed to stand in a closed vessel at room temperature for 3 days. The precipitated crystals are filtered, washed with ethanol. 1.18 g. of 3-aminocarbonyl-6-methyl-9-(N,N-dimethylamino-carbonyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido[1,2-a]pyrimidine is obtained, melting point 220° C.

Workup

  1. filtrationThe precipitated crystals are filtered
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-dd90c19fc3c04d1bb67e95c49ca09c8c
Source dataset
uspto-grants-1982_03
Patent number
US04321377

Reaction notes

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