Methyl iodide → HCID 12831928, compound

HRID 2059065Notes

Reaction equation

HRID 2059065 reaction equation
[CH3:1][N:2]1[CH:7]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[NH:16][C:17]([C:19]2[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=2)=[O:18])[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:27][I:28]>CC(C)=O>[I-:28].[CH3:26][O:25][C:22]1[CH:21]=[CH:20][C:19]([C:17]([NH:16][C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:9][CH2:8][CH:7]2[CH2:6][CH2:5][CH2:4][CH2:3][N+:2]2([CH3:27])[CH3:1])=[O:18])=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 48041Encainide

Product 1

HCID 12831928HCID 12831928, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 7.04 g (0.020 mol) of encainide (I) and 5.68 g. (0.040 mol) of methyl iodide in 100 ml. of acetone was heated at the reflux temperature for 24 hours. The solvent was evaporated and the residue was distributed between H2O and benzene. The aqueous layer was separated, washed twice with benzene, and evaporated in vacuo to obtain a solid, m.p. 75°-80° C.

Workup

  1. customThe solvent was evaporated
  2. customThe aqueous layer was separated
  3. washwashed twice with benzene
  4. customevaporated in vacuo
  5. customto obtain a solid, m.p. 75°-80° C.

Sources & evidence

ORD record
ord-a7f1ca17d65941f99ff943f944838582
Source dataset
uspto-grants-1982_03
Patent number
US04321386

Reaction notes

Loading…