Sodium Hydroxide → HCID 57037309, compound

HRID 2059075Notes

Reaction equation

C([S:4][CH2:5][CH:6]([C:19]([F:22])([F:21])[F:20])[C:7]([N:9]1[C@H:13]([C:14]([O:16]C)=[O:15])[C@@H:12]([CH3:18])[O:11][CH2:10]1)=[O:8])(=O)C.[OH-].[Na+]>>[SH:4][CH2:5][CH:6]([C:19]([F:22])([F:21])[F:20])[C:7]([N:9]1[C@H:13]([C:14]([OH:16])=[O:15])[C@@H:12]([CH3:18])[O:11][CH2:10]1)=[O:8]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86738300HCID 86738300, compound

Product 1

HCID 57037309HCID 57037309, compound

Procedure

The product from part (c) is treated with sodium hydroxide according to the procedure of Example 1(c) to yield (4S-trans)-3-(3-mercapto-2-trifluoromethyl-1-oxopropyl)-5-methyl-4-oxazolidinecarboxylic acid. This diastereoisomeric mixture can then be separated into the individual isomers.

Sources & evidence

ORD record: ord-ae7fd4c0c53c44c2a4ef63a15d0bb4d6
Source dataset: uspto-grants-1982_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04321392

Reaction notes

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