Water → 2-chloro-2',6'-dimethyl-N-(4-isopropylpyrazol-1-yl-methyl)-acetanilide

Participants

Reaction Steps

A solution of 12.1 parts by weight of 4-isopropylpyrazole and 5.6 parts by weight of potassium hydroxide in 30 parts by volume of water was added at 25° C., with vigorous stirring, to a solution of 24.6 parts by weight of 2-chloro-N-chloromethyl-2',6'-dimethylacetanilide and 0.5 part by weight of triethylbenzylammonium chloride in 100 parts by volume of chloroform and stirring was continued for 4 hours at 25° C. The organic phase was washed with three times 50 parts by volume of water, dried over sodium sulfate and evaporated under reduced pressure at 50° C. to give 26.2 parts by weight of 2-chloro-2',6'-dimethyl-N-(4-isopropylpyrazol-1-yl-methyl)-acetanilide of melting point 58° C.

Provenance & Evidence