Sodium Chloride → HCID 135430559, compound

Participants

Reaction Steps

A mixture of 0.44 g of 1-(4-methoxy-3-acetoxyphenyl)-4-methyl-5-ethyl-7-acetoxy-8-methoxy-5H-2,3-benzodiazepine, 8 ml of ethanol, 8 ml of water and 0.4 g of potassium hydroxide is stirred in nitrogen atmosphere for 15 minutes. 50 ml of 20% aqueous sodium chloride solution and 0.6 g of ammonium chloride are added to the solution. The precipitate is separated and recrystallized from 7.5 ml of 20% aqueous dimethyl formamide. 0.23 g of pure 1-(4-methoxy-3-hydroxyphenyl)-4-methyl-5-ethyl-7-hydroxy-8-methoxy-5H-2,3-benzodiazepine are obtained; the product decomposes at 210°-212° C. This compound is identical with the product obtained according to Example 26, and no depression of melting point can be observed when admixing the two products with each other.

Provenance & Evidence