Dimethoxymethane → HCID 53683694, compound

Participants

Reaction Steps

Analogously to Example 1, 1.0 g of 19-acetoxy-17-hexanoyloxy-4-pregnene-3,20-dione in 7 ml of methylene chloride is reacted with 4.9 ml of formaldehyde dimethylacetal and a mixture of 200 mg of phosphorus pentoxide and 1.5 g of kieselguhr W 20, and worked up. The crude product is purified on 110 g of silica gel with a hexane/acetone gradient (0-20% acetone), thus isolating 563 mg of 19-acetoxy-17-hexanoyloxy-6-methylene-4-pregnene-3,20-dione, mp 111°-112° C.

Provenance & Evidence