HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethoxymethane → 17,21-Diacetoxy-6-methylene-4-pregnene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethoxymethane | HCID 8020 | — |
| Reactant | Phosphorus oxybromide | HCID 24613 | — |
| Reactant | 17,21-Bis(acetyloxy)pregn-4-ene-3,20-dione | HCID 102165 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 17,21-Diacetoxy-6-methylene-4-pregnene-3,20-dione | HCID 12951771 | — |
Reaction Steps
Analogously to Example 9, 2.0 g of 17,21-diacetoxy-4-pregnene-3,20-dione in 60 ml of methylene chloride is reacted with 60 ml of formaldehyde dimethylacetal, 2.0 g of sodium acetate, and 12.6 g of phosphorus oxybromide, and worked up, thus isolating 1.68 g of 17,21-diacetoxy-6-methylene-4-pregnene-3,20-dione, mp 226°-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04322349 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-7bd1b1443d4f4ef6a1c312bb8a82d656 |
| Source note | uspto-grants-1982_03 |