HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 21-Acetoxy-17alpha-hydroxy-6-methylene-4-pregnene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 11-Deoxycortisol 21-acetate | HCID 101816 | — |
| Product | 21-Acetoxy-17alpha-hydroxy-6-methylene-4-pregnene-3,20-dione | HCID 12951790 | 66% |
Reaction Steps
1.0 g of 21-acetoxy-17α-hydroxy-4-pregnene-3,20-dione is reacted, using 2.0 g of p-toluenesulfonic acid, analogously to Example 42 and purified, thus obtaining 680 mg of 21-acetoxy-17α-hydroxy-6-methylene-4-pregnene-3,20-dione, mp 194°-196° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04322349 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-a95dec3c50e7486894b97a753c830196 |
| Source note | uspto-grants-1982_03 |