Pyridine → HCID 13036818, compound

Participants

Reaction Steps

To 140 ml. of ethylene glycol is added 24 gm (0.08 mole) of 4-amino-3-mercapto[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-benzene, 14 gm. (0.08 mole) ethyl bromoacetate, and 6.4 gm. (0.08 mole) of pyridine. The solution is stirred and heated at 105°-110° for 8 hours. At the end of this period the solution is cooled and poured into 800 ml of ice-water. The resultant precipitate is filtered. The precipitate is air dried and recrystallized from ethyl acetate/hexane to give 14 gm of 7-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)-ethyl]-2H-1,4-benzothiazin-3(4H)-one, m.p. 230°-232°.

Provenance & Evidence