Propylene Oxide → HCID 20546020, compound

Participants

Reaction Steps

To a solution of 4-amino-3-mercapto[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-benzene in ethanol containing a trace of sodium ethoxide can be added propylene oxide to the cold solution. An exothermic reaction occurs. When reaction subsides, the solution is heated on the steam bath. The product can be isolated and distilled to give 3,4-dihydro-3-methyl-7-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)-ethyl]-2H-1,4-benzothiazine.

Provenance & Evidence