Nitrogen → HCID 86738314, compound

Participants

Reaction Steps

Two hundred ninety-five grams (1.3 mol) of monoethyl phenylmalonate chloride in 500 ml of absolute tetrahydrofuran were added dropwise, at room temperature, to a cooled mixture of 236 gm (1.3 mol) of 2-(3',4'-dimethoxyphenyl)-ethylamine, 171 gm of triethylamine, and 500 ml of absolute tetrahydrofuran, under stirring and in a protective N2 atmosphere. After the reaction ended, the precipitated triethylammonium chloride was suction filtered, the filtrate was concentrated, and the solid residue was distributed between water and methylene chloride. The organic phase was dried over Na2SO4. After the solvent evaporated, the product was recrystallized from ethyl acetate.

Provenance & Evidence