反应详情

5 ml of ethanol were added to a mixture of 4.8 g of 4,7-dichloroquinazoline and 3.0 g of p-anisidine. The resulting mixture was heated, whereupon the solids dissolved and then the mixture immediately solidified. After cooling, the solidified compound was collected and washed with, in turn, ethanol, dilute aqueous sodium hydroxide and water. The resulting crystals were recrystallized from ethanol to give 4.0 g (yield 51%) of the desired Compound No. 9 in the form of pale yellow plates melting at 177°-179° C.

1. temperatureThe resulting mixture was heated, whereupon the solids
2. dissolutiondissolved
3. temperatureAfter cooling
4. customthe solidified compound was collected
5. washwashed with, in turn, ethanol, dilute aqueous sodium hydroxide and water
6. customThe resulting crystals were recrystallized from ethanol