P-Anisidine → HCID 20450369, compound

HRID 2059194Notes

Reaction equation

HRID 2059194 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>C(O)C>[ClH:1].[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:21][C:18]3[CH:19]=[CH:20][C:15]([O:14][CH3:13])=[CH:16][CH:17]=3)=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 7732P-AnisidineHCID 2418814,7-Dichloroquinazoline

Product 1

HCID 20450369HCID 20450369, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 ml of ethanol were added to a mixture of 4.8 g of 4,7-dichloroquinazoline and 3.0 g of p-anisidine. The resulting mixture was heated, whereupon the solids dissolved and the reaction mixture immediately then solidified. After cooling, the solidified product was collected and washed with ethanol and the resulting crystals were recrystallized from ethanol, giving 2.0 g (yield 62%) of the desired Compound No. 10 in the form of a fine pale yellow powder having a melting point of 276°-279° C. (with decomposition).

Workup

  1. temperatureThe resulting mixture was heated, whereupon the solids
  2. dissolutiondissolved
  3. temperatureAfter cooling
  4. customthe solidified product was collected
  5. washwashed with ethanol
  6. customthe resulting crystals were recrystallized from ethanol

Sources & evidence

ORD record
ord-f531d9e4665f407c8178e71353d3ed26
Source dataset
uspto-grants-1982_03
Patent number
US04322420

Reaction notes

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