反应详情

5 ml of ethanol were added to a mixture of 2.3 g of 4-chloro-7-trifluoromethylquinazoline and 1.4 g of p-anisidine. The resulting mixture was heated to dissolve the solids, whereupon the solution solidified immediately. After cooling, the resulting crystals were collected by filtration and washed with, in turn, ethanol, dilute aqueous sodium hydroxide and water. The resulting crystals were recrystallized from ethanol, to give 2.5 g (yield 78%) of the desired Compound No. 51 in the form of colourless needles melting at 190°-194° C.

1. temperatureThe resulting mixture was heated
2. dissolutionto dissolve the solids
3. temperatureAfter cooling
4. filtrationthe resulting crystals were collected by filtration
5. washwashed with, in turn, ethanol, dilute aqueous sodium hydroxide and water
6. customThe resulting crystals were recrystallized from ethanol