HCID 13060676, compound → HCID 13277174, compound

Participants

Reaction Conditions

Reaction Steps

25 g of manganese dioxide are activated in 200 ml of alcohol-free chloroform for 2 hours by azeotropic dehydration. The solution is cooled, whilst stirring, to 10° C., 4.92 g of 5-butyryl-1,6-dimethylbenzimidazole-2-methanol are added and the whole is allowed slowly to return to room temperature and is stirred for 18 hours at room temperature. The solution is filtered, the filtrate evaporated to dryness and the residue recrystallised from chloroform/petroleum ether. 5-butyryl-1,6-dimethylbenzimidazole-2-carboxaldehyde having a melting point of 116.5°-118° is obtained.

Provenance & Evidence