Sodium Acetate → HCID 13277174, compound

HRID 2059217Notes

Reaction equation

HRID 2059217 reaction equation
[C:1]([C:6]1[C:18]([CH3:19])=[CH:17][C:9]2[N:10]([CH3:16])[C:11]([CH:13](Cl)Cl)=[N:12][C:8]=2[CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].C([O-])(=[O:22])C.[Na+]>C(O)C>[C:1]([C:6]1[C:18]([CH3:19])=[CH:17][C:9]2[N:10]([CH3:16])[C:11]([CH:13]=[O:22])=[N:12][C:8]=2[CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 20546796HCID 20546796, compound

Product 1

HCID 13277174HCID 13277174, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.0 g of 5-butyryl-2-dichloromethyl-1,6-dimethylbenzimidazole are dissolved in 100 ml of ethanol. 50 ml of a 4 N sodium acetate solution are added and the solution is refluxed for 5 hours. The solution is evaporated to dryness under reduced pressure and recrystallised from ethyl acetate/cyclohexane. 5-butyryl-1,6-dimethylbenzimidazole-2-carboxaldehyde having a melting point of 116°-118° is obtained.

Workup

  1. temperaturethe solution is refluxed for 5 hours
  2. customThe solution is evaporated to dryness under reduced pressure
  3. customrecrystallised from ethyl acetate/cyclohexane

Sources & evidence

ORD record
ord-fbbef363ac714119b8b4b5fef46c4926
Source dataset
uspto-grants-1982_03
Patent number
US04322431

Reaction notes

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