反应详情

温度

5 °C

3-(4-(Trifluoromethyl)phenyl)-2,3-dibromopropionitrile (2098 grams) was dissolved in methanol and chilled to 5° C. in an ice-bath. Next, over a 2 hour period, sodium methylate (95%) was added keeping the temperature between 5°-10° C. The reaction mixture was then allowed to warm to room temperature, was stirred for 33 hours, and was stripped to near dryness. Upon the addition of 8 l. ether the organic-inorganic mixture was slurried, slowly filtered, and the filtrate stripped again, resulting in a brown oil. NMR analysis confirmed that the oil was the desired mixture of products.

1. custombetween 5°-10° C
2. temperatureto warm to room temperature
3. additionUpon the addition of 8 l
4. filtrationslowly filtered
5. customresulting in a brown oil
6. additionmixture of products