Methyl iodide → HCID 13035563, compound

Participants

Reaction Steps

2,6-Dichloro-N-(5-(4-chlorophenyl)-3-isoxazolyl)benzamide (1 gram prepared according to the teaching of synthesis route III and Example 15) and sodium methoxide (160 milligrams in 100 ml. methanol) were placed in a reaction vessel and stirred for about 15 minutes. Excess methyl iodide was added and the reaction mixture was then heated to reflux for 4 hours. Upon cooling a solid formed which was filtered and then recrystallized from ethanol. NMR analysis confirmed that the final product was a mixture of exo- and endo-alkylated isoxazole, m.p.=175°-178° C.

Provenance & Evidence