Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 3-(Trifluoromethyl)benzoylacetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Benzoic acid, 3-(trifluoromethyl)-, ethyl ester | HCID 144790 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-(Trifluoromethyl)benzoylacetonitrile | HCID 520304 | 59.3% |
반응 단계
NaH (4.8 grams in a 50% oil dispersion) was placed in a 500 ml. 3-necked flask under an atmosphere of nitrogen and, after the addition of 80 ml. of THF, the mixture was heated to reflux. Next a solution of ethyl-3-(trifluoromethyl)benzoate (19 grams), acetonitrile, (5 grams) and THF (20 ml.) was added. Reflux was continued for 2 hours and then the reaction mixture was cooled and 250 ml. ether added. The organic layer was first extracted with 1 N NaOH, and then washed with brine and dried. Removal of the solvent afforded 11 grams of solid product, m.p. 58°-60° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04322429 |
| 출처 데이터셋 | uspto-grants-1982_03 |
| ORD ID | ord-3995adbe6b7940e3b474099fd603358c |
| 출처 메모 | uspto-grants-1982_03 |