HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 4-(4-(Trifluoromethyl)phenyl)-5-aminoisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 3-Dimethylamino-2-(4-(trifluoromethyl)phenyl)-acrylonitrile | HCID 54490746 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-(Trifluoromethyl)phenyl)-5-aminoisoxazole | HCID 20546740 | — |
Reaction Steps
3-Dimethylamino-2-(4-(trifluoromethyl)phenyl)-acrylonitrile (2.5 g), and NH2OH.HCl (1.5 g) were refluxed in ethanol for 2 hours. After evaporation of the solvent, water was added and the final product was filtered, recrystallized from methylene chloride, and identified by NMR analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04322429 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-5c70dee26f8c4e3eb0a905a653405203 |
| Source note | uspto-grants-1982_03 |