HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Methoxy-spiro(cyclohexane-1,2'-indan)-1'-one → 4'-Hydroxy-spiro(cyclohexane-1,2'-indan)-1'-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Methoxy-spiro(cyclohexane-1,2'-indan)-1'-one | HCID 20546905 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 4'-Hydroxy-spiro(cyclohexane-1,2'-indan)-1'-one | HCID 20546904 | — |
Reaction Steps
5.6 g of 4'-methoxy-spiro(cyclohexane-1,2'-indan)-1'-one in 80 ml acetic acid and 20 ml 48% (w/w) aqueous hydrogen bromide are refluxed for 20 hours. The mixture is evaporated, diluted with water and extracted with ether. Evaporation of the solvent yields 4'-hydroxy-spiro(cyclohexane-1,2'-indan)-1'-one; M.Pt. 162°-164° (from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04322437 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-1dd032638e1043389ca7aed476d275f3 |
| Source note | uspto-grants-1982_03 |