HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anisole → HCID 20545919, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anisole | HCID 7519 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 4-(4-chlorophenyl)-2,2-dimethylbut-3-enoate | HCID 54397833 | — |
| Product | HCID 20545919 | HCID 20545919 | — |
Reaction Steps
Following the method of Rudenko et al*, anisole was alkylated with ethyl 4-(4-chlorophenyl)-2,2-dimethylbut-3-enoate. Hydrolysis of the ester with potassium hydroxide gave 4-(4-chlorophenyl)-4-(4-methoxyphenyl)-2,2-dimethylbutanoic acid, purified by washing with sodium bicarbonate solution and water. Recrystallization from ethyl acetate-light petrol (b.p. 60°-80°) afforded the acid as white prisms, m.p. 139°-142° (63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04322370 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-6813e334ce1e43d2b2d32dc223ad4161 |
| Source note | uspto-grants-1982_03 |