反应详情

1.56 g (4.27 mmol) [4-(7-Chloro-1-oxo-1,2-dihydro-isoquinolin-6-yloxy)-piperidin-1-yl]-acetic acid ethyl ester (41) were dissolved in 20 mL of methanol and 20 ml of 2N NaOH were added. After stirring for 1 h at room temperature, the solvent was removed i. vac. and the residue was dissolved in water. The aqueous solution was neutralized by adding 2 N HCl. Filtration of the precipitate and drying gave 856 mg of the title compound. Rt=0.82 min (Method B). Detected mass: 337.1 (M+H+).

1. customthe solvent was removed i
2. dissolutionand the residue was dissolved in water
3. additionby adding 2 N HCl
4. filtrationFiltration of the precipitate
5. customdrying