Benzyl Bromide → 1-Benzyl-4-iodo-1H-pyrazole

Participants

Reaction Steps

To a stirred suspension of 4-iodo-1H-pyrazole (1.50 g, 7.73 mmol) and potassium carbonate (2.67 g, 19.3 mmol) in acetone was added benzyl bromide (0.96 mL, 8.07 mmol) and the reaction was refluxed for 3 h. After cooling to room temperature the mixture was concentrated onto silica gel in vacuo and eluted through a short silica plug (sequential elution—hexane, 10% diethyl ether in hexanes) to provide the title compound as a white solid (2.12 g, 97% yield).

Provenance & Evidence