HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → Ethyl 2-amino-4-(propan-2-yl)-1,3-thiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 2-bromo-4-methyl-3-oxopentanoate | HCID 13015595 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-amino-4-(propan-2-yl)-1,3-thiazole-5-carboxylate | HCID 824436 | 40.6% |
Reaction Steps
A solution of thiourea (1.1 g) in ethanol (10 mL) was brought to reflux. Ethyl 2-bromo-4-methyl-3-oxopentanoate (3.0 g) was then added and the reaction mixture refluxed further for 1 h. The reaction was complete (by TLC) and was concentrated in vacuum. Flash chromatography (100% DCM→90:10 DCM:MeOH) afforded the product (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278302B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4fcb63310a5f43baa5fe418e7f9b8e1b |
| Source note | uspto-grants-2012_10 |