HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Ethyl 3-(chlorocarbonyl)-5-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1,3-Benzenedicarboxylic acid, 5-nitro-, 1-ethyl ester | HCID 89872 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-(chlorocarbonyl)-5-nitrobenzoate | HCID 3023043 | — |
Reaction Steps
To a solution of 5-nitroisophtalic acid monoethyl ester (80 g) in DCM (700 ml) at 25° C. was added 2M oxalyl chloride solution in DCM (63 ml), and DMF (5 ml). The reaction was stirred for 2 h and then concentrated in vacuum. The residue was triturated with toluene and again concentrated in vacuum leaving the title compound (60 g). Rt=1.40 min for derivatised methylester (method D).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278302B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-1ab2191473b343e5bea18484e260f520 |
| Source note | uspto-grants-2012_10 |