HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-[(Azetidin-3-yl)oxy]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 3-hydroxyazetidine-1-carboxylate | HCID 2756801 | — |
| Product | 2-[(Azetidin-3-yl)oxy]pyridine | HCID 59418282 | — |
Reaction Steps
Preparation of compound P21. Compound P21 was prepared by deprotection of C73 with trifluoroacetic acid as described for t-butyl 3-hydroxyazetidine-1-carboxylate in the preparation of C19 in Example 3, before being used in the coupling step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278295B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-04f983c017ba471ebf16ed8f2edcb8c2 |
| Source note | uspto-grants-2012_10 |