Potassium Acetate → HCID 178457730, compound

Participants

Reaction Conditions

Reaction Steps

To the product of Example 1 (0.198 g, 0.479 mmol) in DMSO (5.0 mL) was added potassium acetate (0.188 g, 1.916 mmol), palladium(II) acetate (5.38 mg, 0.024 mmol), and dppf (0.053 g, 0.096 mmol). The reaction was stirred under a CO atmosphere and heated at 120° C. for 30 min. The reaction was diluted with EtOAc, washed with aq. HCl (1M) and concentrated. The residue was purified by preparative HPLC (Non-Polar Method). The material was further purified by flash chromatography on silica gel eluted with EtOH to afford the title compound. HPLC/MS: 379.0 (M+1); Rt=2.62 min.

Provenance & Evidence