Sodium borohydride → HCID 69080977, compound

Participants

Reaction Conditions

Reaction Steps

The product of Step B (2.41 g, 6.69 mmol) was dissolved in MeOH (60 mL), cooled to 0° C., and NaBH4 (0.51 g, 13.37 mmol) was added portionwise. The reaction was aged for 45 min and was quenched with saturated aq NH4Cl. The reaction was concentrated. The resulting paste was diluted in EtOAc and washed with brine. The organic portion was isolated, dried with Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on silica gel gradient eluted with 0 to 100% EtOAc/hexane, affording a mixture of two diastereomers.

Provenance & Evidence