1,2-Dichloroethane → HCID 178457733, compound

Participants

Reaction Steps

To the product of Example 188 (100 mg, 0.343 mmol), DIPEA (0.15 mL 0.86 mmol), 2,3-dihydro-1H-indole (0.04 ml, 0.36 mmol) and HOBt (55.2 mg, 0.36 mmol) in 1.4 mL DMF was added EDC (69.1 mg, 0.36 mmol). The reaction aged at rt for 3.5 h. The reaction was diluted with EtOAc and washed with aq HCl (2 M) and water. The organic portion was partially concentrated and the product was allowed to crystallize. The mixture was diluted with 80% EtOAc/20% hexane before the product was isolated by filtration. It was then washed with 80% EtOAc/20% hexane to afford the title compound. HPLC/MS: 393.0 (M+1); Rt=2.63 min.

Provenance & Evidence