1-Boc-octahydropyrrolo(3,4-b)pyridine → 4'-((4aR,7aR)-tetrahydro-1H-pyrrolo[3,4-b]pyridin-6(2H,7H,7aH)-yl)-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazolin]-2'-amine

Participants

Reaction Steps

The title compound was prepared using the procedures outlined in Examples 1G and 1H, substituting tert-butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate (CAS# 159877-36-8) for the product from Example 1D. 1H NMR (300 MHz, CDCl3) δ 4.38-4.47 (m, 2 H), 3.70-3.82 (m, 2 H), 3.38-3.52 (m, 2 H), 3.31 (td, 1 H), 3.00 (dt, 1 H), 2.57-2.69 (m, 3 H), 2.16-2.26 (m, 2 H), 1.96-2.07 (m, 1 H), 1.79-1.92 (m, 2 H), 1.64-1.76 (m, 6 H), 1.42-1.59 (m, 6 H). MS (DCI+) m/z 328 (M+H).

Provenance & Evidence