HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(((1,1-dimethylethoxy)carbonyl)amino)-4-piperidinecarboxylate → methyl 4-amino-1-(2'-amino-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazoline]-4'-yl)piperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(((1,1-dimethylethoxy)carbonyl)amino)-4-piperidinecarboxylate | HCID 14537079 | — |
| Reactant | 2'-amino-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazolin]-4'-yl 4-methylbenzenesulfonate | HCID 86634333 | — |
| Product | methyl 4-amino-1-(2'-amino-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazoline]-4'-yl)piperidine-4-carboxylate | HCID 44231854 | — |
Reaction Steps
The title product was prepared using the procedures outlined in Examples 1G and 1H, substituting methyl 4-(tert-butoxycarbonylamino)piperidine-4-carboxylate (CAS# 115655-44-2) for the product from Example 1D. 1H NMR (300 MHz, CDCl3) δ 4.50 (s, 2 H), 3.74 (s, 3 H), 3.30-3.36 (m, 4 H), 2.45 (t, J=4.58 Hz, 2 H), 2.04-2.21 (m, 4 H), 1.79-1.92 (m, J=4.07 Hz, 2 H), 1.49-1.73 (m, 10 H). MS (DCI+) m/z 360 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278313B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-63f64f524da94b9ab0c8443e3a825a39 |
| Source note | uspto-grants-2012_10 |