N-(3-Iodo-4-methylphenyl)-4-((4methylpiperazin-1-yl) methyl)-3-(trifluoromethyl)benzamide → 1-methyl-5-({2-methyl-5-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbonyl)amino]phenyl}ethynyl)-1H-imidazole-2-carboxamide

HRID 2059804Notes

Reaction equation

HRID 2059804 reaction equation
[C:1]([C:3]1[N:7]([CH3:8])[C:6]([C:9]([NH2:11])=[O:10])=[N:5][CH:4]=1)#[CH:2].I[C:13]1[CH:14]=[C:15]([NH:20][C:21](=[O:40])[C:22]2[CH:27]=[CH:26][C:25]([CH2:28][N:29]3[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]3)=[C:24]([C:36]([F:39])([F:38])[F:37])[CH:23]=2)[CH:16]=[CH:17][C:18]=1[CH3:19]>>[CH3:8][N:7]1[C:3]([C:1]#[C:2][C:17]2[CH:16]=[C:15]([NH:20][C:21]([C:22]3[CH:27]=[CH:26][C:25]([CH2:28][N:29]4[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]4)=[C:24]([C:36]([F:39])([F:37])[F:38])[CH:23]=3)=[O:40])[CH:14]=[CH:13][C:18]=2[CH3:19])=[CH:4][N:5]=[C:6]1[C:9]([NH2:11])=[O:10]

Participants

3

Reactant 2

HCID 46838911N-(3-Iodo-4-methylphenyl)-4-((4methylpiperazin-1-yl) methyl)-3-(trifluoromethyl)benzamideHCID 577374055-Ethynyl-1-methyl-1h-imidazole-2-carboxamide

Product 1

HCID 577373791-methyl-5-({2-methyl-5-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbonyl)amino]phenyl}ethynyl)-1H-imidazole-2-carboxamide

Procedure

The title compound can be synthesized from 5-ethynyl-1-methyl-1H-imidazole-2-carboxylic acid amide and N-(3-iodo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide in a manner similar to that described for Example 2. 5-ethynyl-1-methyl-1H-imidazole-2-carboxylic acid amide is prepared as in Example 2.

Sources & evidence

ORD record
ord-da9c0d442fe047f5b78a7e65c1dc2ea1
Source dataset
uspto-grants-2012_10
Patent number
US08278307B2

Reaction notes

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