Hydrochloric Acid → HCID 16067579, compound

Participants

Reaction Steps

To a solution of methyl 5-(diisopropylamino)-5-oxo-3-phenyl-4-pyridin-3-ylpentanoate (Diastereomer 2, 1.095 g, 2.863 mmol) in EtOH (13 mL) was added water (15 mL) followed by 1 N aqueous NaOH (5.725 mL). The reaction mixture was stirred at room temperature. After 24 h, 1N HCl (5.725 mL) was added. The mixture was then extracted with CH2Cl2 (4×). The combined organic layers were dried over anhydrous Na2SO4 and concentrated to give a light yellow solid.

Provenance & Evidence